Antibiotic damages gut microbiota, affect bone health. A new study analyzed the side effects of antibiotic treatment. The results found that antibiotics interfere with gut bacteria to impair postpubertal skeletal development.
The trillions of bacteria present in our bodies support the gastrointestinal and immune systems and plays key role for our health. They also help the body in the process of absorbing nutrients from foods and supplements.
Scientists from the Medical University of South Carolina (MUSC) in Charleston looked at the impact of antibiotics on postpubertal skeletal development. They published the findings of their study in the American Journal of Pathology.
The research shows that disruption of the gut microbiota by antibiotic causes a pro-inflammatory response, leading to less bone resorption.
For the study, the team gave mice treatment with three antibiotics. They found disruption in the gut microbiota of the mice. In addition, they also demostrates that a cocktail treatment resulted in some changes to the trabecular bone.
The researchers explains that size and activity levels of the osteoblasts, the number of osteoclast cells, was increased. They concludes that due to this increase of osteoclast activity, a specific immune response changes in the microbiota.
“Our study is actually able to dive into specific adaptive and innate immune cell mechanisms within the bone marrow environment to show that there is an effect on the bone cells,” said study co-author Jessica D. Hathaway-Schrader, Ph.D.
An aim behind this study is to call need for the development of noninvasive therapeutic to treat skeletal deterioration.